This is actually a fairly boring frame. It makes some dubious claims, but sets up some really wild creatocrap to come. The subtle comparison between the Neanderthal skull-cap (calvaria) and Charles Darwin's dome is almost clever.
Then there is the "diabolical Beard of Evil" worn by the "professor." Compare with this bit of sillyness:
This is such a well known piece of iconography that it has it's own webpage, The Beard of Evil! OOOH Scarrrrry!!! And, like a lot of Jack Chick, it is terribly passé witnessed by this entry in the The Evil Overlord List,
I will not grow a goatee. Yes, it is true that in the old days they made you look sinister. Unfortunately, these days they only make you look like a disaffected member of Generation X.
My beard shows that I have a rugged and yet well preserved phiz. Oh, and totally trustworthy.
As I said, mostly boring. Is the 1857 Neanderthal skull cap really "The first and most famous clue to early man?" The original drawing by anatomist Hermann Schaafhausen's is below.
Chick's drawing compares well with recent photos such as this:
I personally doubt that most people would think of this as the "The first and most famous clue to early man?" But, I don't think it really matters.